Although a number of differently flavored antacids have been introduced recently, no blinded comparative palatability evaluations have been conducted since 1977. A comparative, randomized, single-blind evaluation of over-the-counter aluminum and magnesium antacid suspensions was conducted to determine their relative palatability. Thirty healthy volunteers were asked to evaluate 14 antacids for smell, taste, texture, and aftertaste. The study found a statistically significant difference in all rated characteristics of antacids. Mylanta Cherry Creme (score 24.4 out of a possible 36) and Mylanta Double Strength Cool Mint Creme (score 24.2) were ranked highest in overall palatability; Riopan Plus 2 (score 18.7) and Di-Gel Lemon Orange (score 18.0) were ranked lowest. The study concluded that the palatability of various antacid suspensions differs markedly and should be considered when selecting an antacid product.